Limited by early technological capabilities, growth hormone could only be processed using freeze-drying techniques. This freeze-drying process partially alters the spatial structure of growth hormone. Long-term use of growth hormone with a structure inconsistent with its natural form may introduce unpredictable safety risks to the body.Therefore, the field of growth hormone research has taken on the challenge of developing aqueous injections. Since protein drugs undergo oxidation, deamination, and polymerization reactions in aqueous solutions, leading to loss of biological activity, maintaining protein stability in aqueous solutions for nearly two years presents a significant challenge.
Proteins are classified by different structures. The primary structure refers to the sequence of amino acids in the polypeptide chain;Secondary structure refers to the folding of peptide chains into local spatial conformations, such as sheets or helices. Building upon these secondary structures, the polypeptide chains of a protein further coil or fold to form a three-dimensional spatial structure with specific patterns, known as the tertiary structure. Powdered growth hormone achieves a primary structure identical to that of naturally secreted human growth hormone. Only when the protein's folding in its tertiary structure perfectly matches the natural structure can it ensure optimal functionality.In 2005, through relentless efforts by Jinse researchers, the use of amorphous protein stabilization technology eliminated the freeze-drying process, leading to the successful launch of the Asia-Pacific region's first liquid growth hormone—Saizeng Liquid. For protein macromolecular drugs to exhibit biological activity, not only must their primary structure match the natural form, but more critically, their tertiary structure must be identical to the natural structure.The transition from powder to solution for growth hormone marked the first achievement of complete spatial structural alignment with the natural form, resulting in higher activity and superior efficacy.
The solution employs unique protein liquid stabilization technology, preserving the drug's spatial structure without inducing polymerization and achieving zero antibody detection.
Is the growth hormone solution or powder better?The liquid formulation has become the mainstream form of growth hormone internationally. In markets like Europe and the United States, liquid formulations have gradually replaced powder formulations. In Australia, over 70% of growth hormone administered is in liquid form, as it significantly outperforms powder formulations in terms of potency, safety, and convenience, making it more suitable for clinical use. Therefore, the liquid formulation has become the inevitable trend in growth hormone development.