Vitamin E (Tocopherol): High doses (exceeding 100 mg daily) and long-term use may cause various nonspecific discomforts. Use exceeding six months may lead to adverse reactions such as platelet aggregation and thrombosis. Daily doses over 400 mg taken for more than one year, especially when combined with estrogen, significantly increase the risk of thrombophlebitis.
Vitamin C: High doses may cause diarrhea and lead to urinary tract cystine precipitation or oxalate stone formation.
Penicillamine: Prolonged use may irritate the kidneys and cause leukopenia.
Trace Elements:
Excessive levels in the body can cause various adverse effects. Excess zinc may induce nausea, vomiting, and diarrhea. Excess cobalt is toxic to the myocardium, causing heart failure and potentially death.Selenium excess may cause hair loss, nail abnormalities, and skin depigmentation; selenium poisoning can manifest as gastrointestinal dysfunction, dizziness, loss of libido, fatigue, nervousness, and depression. Animal studies indicate selenium may also cause embryonic malformations. Excessive iron in the human body produces significant adverse effects on the pancreas and gonads.
Anti-aging Chinese Medicinal Herbs:
Though renowned for low or no toxicity, these herbs must not be abused.
For instance, ginseng is classified as a premium anti-aging herb, but high doses (e.g., over 3 grams of ginseng root daily) can induce "ginseng abuse syndrome."Deer antler extract injections may cause rashes, anaphylactic shock, acute cardiogenic cerebral hypoxia syndrome, palpitations, vomiting, nausea, abdominal pain, and exfoliative dermatitis. Salvia miltiorrhiza injections can induce menorrhagia, generalized weakness, drowsiness, headaches, nasal mucosal bleeding, and gingival hemorrhage.Honey, though historically regarded as an elixir of longevity, has been associated with frequent poisoning incidents. Polygonum multiflorum (He Shou Wu) consumption may induce paroxysmal convulsions, agitation, or even respiratory paralysis. Caution is advised with long-term use of certain compound formulations containing anti-aging herbs.Excessive intake of Shuangbaosu (containing ginseng and royal jelly) can cause extreme central nervous system excitation, potentially leading to mania. Liuwei Dihuang Pills may induce urticaria-type drug rashes. The traditional formula of Shenrong Weisheng Pills contains cinnabar, which can cause mercury poisoning with prolonged use.