Clinical applications indicate that high-dose vitamin B2 demonstrates superior efficacy compared to the commonly used migraine medication flunarizine hydrochloride, with fewer side effects and lower cost. The therapeutic effect of vitamin B2 may stem from its enhancement of cellular mitochondrial energy potential. When using vitamin B2 for migraine prevention and treatment, it is most effective for moderate patients experiencing only a few migraines per month, with optimal results typically achieved after three months of use.The recommended daily dosage of vitamin B2 is generally around 400 milligrams.